Publications by authors named "T El Khassawna"

Background: Accumulation of malignant plasma cells in the bone marrow causes lytic bone lesions in 80% of multiple myeloma patients. Frequently fracturing, they are challenging to treat surgically. Myeloma cells surviving treatment in the presumably protective environment of bone lesions impede their healing by continued impact on bone turnover and can explain regular progression of patients without detectable minimal residual disease (MRD).

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The field of bone regeneration has primarily focused on investigating fracture healing and nonunion in isolated musculoskeletal injuries. Compared to isolated fractures, which frequently heal well, fractures in patients with multiple bodily injuries (polytrauma) may exhibit impaired healing. While some papers have reported the overall cytokine response to polytrauma conditions, significant gaps in our understanding remain in how fractures heal differently in polytrauma patients.

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Biomechanical tests typically involve bending, compression, or shear stress, while fall tests are less common. The main challenge in performing fall tests is the non-reproducible directionality of bone when tested with soft tissue. Upon removal of the soft tissue, the explanted bone's resistance to impact diminishes.

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Article Synopsis
  • - Dislocations of the knee are extremely rare, making up less than 0.02% of all muscle and bone injuries.
  • - A case study details a patient who dislocated their knee from a low-impact injury during a sports event, leading to concerns about compartment syndrome and nerve/vessel damage.
  • - The report emphasizes that severe knee dislocations should be treated urgently with closed reduction, and that complications like compartment syndrome may require immediate surgical intervention.
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