Publications by authors named "T Eichkorn"
Introduction: Brain metastases (BM) are the most common malignancy in the central nervous system (CNS) and observed in approximately 30% of cancer patients. Brainstem metastases (BSM) are challenging because of their location and the associated neurological risks. There are still no general therapeutic recommendations in this setting.
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- Primary optic nerve sheath meningiomas (ONSMs) are benign tumors that can cause gradual vision loss, and radiation therapy, particularly proton therapy, is key for treatment as it may improve visual function while minimizing side effects.* -
- In a study of 32 patients treated with proton beam radiotherapy, results showed a 100% local control rate after 5 years and 84.4% of patients experienced improved or stable vision, despite a 9.4% occurrence of radiation-induced optic neuropathy (RION).* -
- The findings support proton beam therapy as a safe and effective option for ONSM treatment, though further research is needed to compare its effectiveness against traditional photon radiotherapy.*
(1) Background: Recent publications foster stereotactic body radiotherapy (SBRT) in patients with adrenal oligometastases or oligoprogression. However, local control (LC) after non-adaptive SBRT shows the potential for improvement. Online adaptive MR-guided SBRT (MRgSBRT) improves tumor coverage and organ-at-risk (OAR) sparing.
View Article and Find Full Text PDFBackground And Purpose: After surgical resection of brain metastases (BM), radiotherapy (RT) is indicated. Postoperative stereotactic radiosurgery (SRS) reduces the risk of local progression and neurocognitive decline compared to whole brain radiotherapy (WBRT). Aside from the optimal dose and fractionation, little is known about the combination of systemic therapy and postoperative fractionated stereotactic radiotherapy (fSRT), especially regarding tumour control and toxicity.
View Article and Find Full Text PDFBackground: While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring.
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