An analytic, efficient and optimal readout algorithm for compact interferometers based on deep frequency modulation.

Compact laser interferometers with large dynamic range are one of the core emerging tools to improve low frequency performance in gravitational wave detectors by providing local displacement sensing with sub 1 precision. Strong sinusoidal frequency modulations are used in such laser interferometers to create heterodyne-like photodetector signals from which the phase and other parameters, such as the absolute distance, can be extracted. The nested sinusoidal function in such signals is a challenge for the real-time parameter estimation in low-noise applications.

BTZ-Derived Benzisothiazolinones with In Vitro Activity against .

8-Nitro-1,3-benzothiazin-4-ones (BTZs) are known as potent antitubercular agents. BTZ043 as one of the most advanced compounds has reached clinical trials. The putative oxidation products of BTZ043, namely, the corresponding BTZ sulfoxide and sulfone, were reported in this journal (Tiwari et al.

Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones.

8-Nitro-1,3-benzothiazin-4-ones (BTZs), with BTZ043 and PBTZ169 as the most advanced compounds, represent a new class of potent antitubercular agents, which irreversibly inhibit decaprenylphosphoryl-β-d-ribose-2'-epimerase (DprE1), an enzyme crucial for cell wall synthesis in the pathogen . Synthesis, structural characterization and in vitro testing against DSM 43999 and HRv of halogenated 2-(4-ethoxycarbonylpiperazin-1-yl)-1,3-benzothiazin-4-ones lacking a nitro group are reported. X-ray crystallography reveals that the structure of the BTZ scaffold can significantly deviate from planarity.

Gene-Trait Matching and Prevalence of Nisin Tolerance Systems in .

cheese starter cultures typically contain a mix of many strains and may include variants that produce and/or tolerate the antimicrobial bacteriocin nisin. Nisin is well-established as an effective agent against several undesirable Gram-positive bacteria in cheese and various other foods. In the current study, we have examined the effect of nisin on 710 individual strains during milk fermentations.