Publications by authors named "T Ebata"
Objective: Osteoarthritis (OA) is a degenerative joint disease that has no cure, and current therapies are intended to minimize pain. There is, therefore, a need for effective pharmacologic agents that reverse or slow the progression of joint damage. We report herein on an investigation of the effects of intra-articular injections of ganglioside sugars on the progression of OA in an experimental rabbit model.
View Article and Find Full Text PDFBackground: We previously reported that the balance of short-chain fatty acids and lactic acid in feces affects postoperative infectious complications after major hepatectomy. However, the effect remains unclear in pancreaticoduodenectomy.
Methods: Preoperative fecal samples were collected from 210 patients who underwent pancreaticoduodenectomy at 2 institutions between January 2019 and June 2021.
Article Synopsis
- The study investigates the genetic heterogeneity and molecular profiles of bile tract cancer (BTC) using whole-genome sequencing to identify actionable gene mutations involved in its progression and treatment resistance.
- The analysis of six BTC samples revealed a high average of somatic mutations with a significant prevalence of single nucleotide variants (SNVs), but no matching mutations were found in the existing cancer database.
- Key findings suggest that samples without vascular invasion had a higher mutation prevalence, highlighting specific genes like ADAMTS7, AHNAK2, and CAPN10 that show differences in mutation rates between groups, emphasizing the complexity and genetic diversity of BTC.
Background: A histologically involved surgical margin (R1) is often observed after resection for cholangiocarcinoma. Compared with a negative margin (R0), R1 with invasive carcinoma (R1inv) markedly worsens survival, whereas the prognostic effect of R1 with carcinoma in situ (R1cis) remains controversial.
Methods: Patients who underwent resection for perihilar cholangiocarcinoma between 2002 and 2019 were retrospectively reviewed.