Publications by authors named "T E Zell"

Background: Cancer immunotherapy has revolutionized melanoma treatment, but the high number of non-responders still emphasizes the need for improvement of therapy. One potential avenue for enhancing anti-tumor treatment is through the modulation of coagulation and platelet activity. Both have been found to play an important role in the tumor microenvironment, tumor growth and metastasis.

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Background: Immune checkpoint inhibition has revolutionized melanoma therapy, but many patients show primary or secondary resistance. Biomarkers are, therefore, urgently required to predict response prior to the initiation of therapy and to monitor disease progression.

Methods: In this prospective study, we analyzed the serum C-C motif chemokine ligand 20 (CCL20) concentration using an enzyme-linked immunosorbent assay.

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Article Synopsis
  • Sentinel Lymph Node Biopsy (SLNB) is crucial for staging cutaneous melanoma, and this review evaluates advanced molecular testing methods like gene expression profiling (GEP) and immunohistochemistry (IHC) for predicting sentinel lymph node prognosis compared to traditional approaches.
  • The importance of identifying high-risk melanoma patients is increasing as advancements in therapy reduce the need for SLNB, and molecular testing platforms such as DecisionDx and Merlin Assay are under validation for clinical use.
  • Despite their promise, many tissue-based molecular tests face methodological challenges like small sample sizes and poor correlation with established clinical variables, leading to limited implementation in practice.
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Background: The treatment of melanoma has been revolutionized by the use of immune checkpoint inhibition (ICI), but many patients do not benefit. Furthermore, immune-related adverse events may occur during therapy. A predictive biomarker is needed to reliably identify patients benefitting.

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The addition of PPh H, PPhMeH, PPhH , P(para-Tol)H , PMesH and PH to the two-coordinate Ni N-heterocyclic carbene species [Ni(NHC) ] (NHC=IiPr , IMe , IEt Me ) affords a series of mononuclear, terminal phosphido nickel complexes. Structural characterisation of nine of these compounds shows that they have unusual trans [H-Ni-PR ] or novel trans [R P-Ni-PR ] geometries. The bis-phosphido complexes are more accessible when smaller NHCs (IMe >IEt Me >IiPr ) and phosphines are employed.

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