Lower limb strength differentiates between fallers and non-fallers with multiple sclerosis.

Objective: To determine whether hip flexion (HF), extension (HE), abduction (HA), knee flexion (KF) and extension (KE), and ankle plantarflexion (APF) and dorsiflexion (ADF) Maximum Voluntary Contraction (MVC) differentiates between non-fall and fall history in persons with MS (PwMS) after accounting for age, gender, fatigue, disability, and disease duration.

Design: Secondary analysis of a cross-sectional study.

Setting: Community-based comprehensive MS Center PARTICIPANTS: 172 persons with MS who completed a one-time visit INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: Lower limb (LL) MVC was measured for each muscle group as isometric peak torque (Newton-meter: Nm) of both limbs (Strongest: S; Weakest: W) using a Biodex Dynamometer and normalized by body weight (Nm/kg).

Assessing the relative efficacy of components of opioid-free anaesthesia in adult surgical patients: protocol for a systematic review and component network meta-analysis.

Introduction: The rise of opioid-free anaesthesia (OFA) aims to reduce postoperative pain while reducing opioid-related side effects during surgery. However, the various adjuvant agents used in OFA complicate the evaluation of their effectiveness and risks. Recent reviews question the clinical benefits of OFA, highlighting the need for thorough evaluation.

Evaluation and Application of the Work-Related Asthma Screening Questionnaire-Long Version (WRASQ(L)).

Background: The Work-related Asthma (WRA) Screening Questionnaire-Long Version (WRASQ(L)) is a screening questionnaire that could improve the recognition of WRA.

Objective: To conduct a definitive evaluation of the WRASQ(L) to justify its implementation in clinical settings.

Methods: Employed adults aged 18 to 75 years with asthma confirmed by objective measures and the ability to take time off work were eligible.

Local anaesthetics and chemotherapeutic agents: a systematic review of preclinical evidence of interactions and cancer biology.

Background: Local anaesthetics are widely used for their analgesic and anaesthetic properties in the perioperative setting, including surgical procedures to excise malignant tumours. Simultaneously, chemotherapeutic agents remain a cornerstone of cancer treatment, targeting rapidly dividing cancer cells to inhibit tumour growth. The potential interactions between these two drug classes have drawn increasing attention and there are oncological surgical contexts where their combined use could be considered.