Publications by authors named "T E Van Dyke"
Article Synopsis
- - Craniofacial and alveolar bone defects from various causes (like tumors, trauma, or tooth loss) present significant challenges in tissue engineering and dental surgery, especially in cases of periodontal disease.
- - Specialized pro-resolving lipid mediators (SPMs) like lipoxins, resolvins, protectins, and maresins are being researched for their potential to enhance bone regeneration and restore tissue healing in craniofacial applications.
- - A total of 19 pre-clinical studies examined the effects of SPMs on bone regeneration, showing that SPMs notably increased new bone formation by about 14.85% and reduced defect size, with RvE1 and RvD2 demonstrating
Aim: Polarization of macrophages (Mφ) is a well-controlled axis with considerable consequences in both the pro-inflammatory and resolution phases of inflammation. We aimed to determine if periodontal therapy may instigate M1 to M2 Mφ polarization favoring resolution of inflammation within periodontal tissues.
Methods: Gingival biopsies were excised from subjects diagnosed with Stage III, Grade B periodontitis before and 4-6 weeks after nonsurgical periodontal therapy.
Aims: Periodontitis is a prevalent inflammatory disorder affecting the oral cavity, driven by dysbiotic oral biofilm and host immune response interactions. While the major clinical focus of periodontitis treatment is currently controlling oral biofilm, understanding the immune response is crucial to prevent disease progression. Soluble epoxide hydrolase (sEH) inhibition has shown promise in preventing alveolar bone resorption.
View Article and Find Full Text PDFPurpose: The innate immune response, particularly the reaction of polymorphonuclear neutrophils (PMNs), is crucial in shaping the outcomes of chronic inflammation, fibrosis, or osseointegration following biomaterial implantation. Peri-implantitis or peri-mucositis, inflammatory conditions linked to dental implants, pose a significant threat to implant success. We developed a single-cell analysis approach using a murine model to assess the immune response to implant materials, offering a practical screening tool for potential dental implants.
View Article and Find Full Text PDFChronic inflammation poses challenges to effective cancer treatment. Although anti-inflammatory therapies have shown short-term benefits, their long-term implications may be unfavorable because they fail to initiate the necessary inflammatory responses. Recent research underscores the promise of specialized pro-resolving mediators, which play a role in modulating the cancer microenvironment by promoting the resolution of initiated inflammatory processes and restoring tissue hemostasis.
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