Publications by authors named "T E Valentine"
Article Synopsis
- Chemotherapy-induced neuropathic pain (CINP) is a significant issue for pediatric cancer survivors, and current pain treatments are not effective due to limited understanding of CINP mechanisms.
- This study explores how cisplatin leads to neuroinflammation and increased pain sensitivity through nerve growth factor (NGF) interactions, particularly focusing on macrophage activity in the dorsal root ganglia (DRG).
- The research findings suggest that targeting the NGF-TrkA signaling pathway in macrophages may offer new pain relief strategies for adults who survived childhood cancer.
Background: Fatigue is one of the most disabling symptoms reported by people with multiple sclerosis. Although behavioural and pharmacological interventions might be partly beneficial, their combined effects have not been evaluated for multiple sclerosis fatigue, or examined with sufficient consideration of characteristics that might affect treatment response. In this comparative effectiveness research trial, we compared the effectiveness of cognitive behavioural therapy (CBT), modafinil, and their combination for treating multiple sclerosis fatigue.
View Article and Find Full Text PDFObjective: Advanced nonsmall cell lung cancer (NSCLC) is associated with the highest burden of mental and physical symptoms. Across illnesses, patients' subjective illness beliefs (i.e.
View Article and Find Full Text PDFCisplatin-based chemotherapy is a common treatment for paediatric cancer. Unfortunately, cisplatin treatment causes neuropathic pain, a highly prevalent adverse health related complication in adult childhood cancer survivors. Due to minimal understanding of this condition, there are currently no condition tailored analgesics available.
View Article and Find Full Text PDFLeaf spot diseases are common on field hemp, causing defoliation, and blighting. The most prevalent leaf spot diseases of hemp in Kentucky are Bipolaris leaf spot (), Cercospora leaf spot (), and Septoria leaf spot (). In this study, disease progression, cultivar susceptibility, and yield loss were examined using cultivars from four relatedness groups at two locations and in two growing seasons.
View Article and Find Full Text PDF