Publications by authors named "T E Stanley"
Scientists from diverse backgrounds are underrepresented (UR) in academia. This lack of diversity impedes scientific discovery and innovation. UR scientists tend to conduct research on issues relevant to UR populations, including chronic disease prevention and management, and health disparities.
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- Alzheimer's disease is linked to the misfolding of beta-amyloid and tau proteins, leading to cellular toxicity.
- Activation of the heat shock response (HSR) pathway helps protect against the toxic effects of both beta-amyloid and tau proteins, improving cell function and longevity.
- Small molecules like Geranylgeranylacetone (GGA) and Arimoclomol (AC) can enhance the HSR, providing potential therapeutic strategies for treating Alzheimer's-related tauopathies.
Article Synopsis
- - Mutations in cilia genes are linked to ciliopathies, affecting cell functions such as development and survival, particularly in zebrafish lateral line hair cells.
- - Disruption of cilia due to mutations in IFT genes (ift88 and dync2h1) led to increased hair cell apoptosis and decreased mitochondrial function, suggesting a link between mitochondrial dysfunction and cell death.
- - While these mutations resulted in reduced hair cell regeneration and survival, they did not significantly alter the number of support cells or their proliferation during hair cell development.
Background: The relationship between obesity and episodic memory (i.e., conscious memory for specific events) is hypothesized to be bidirectional.
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- Weight stigma, particularly negative views about fatness, is linked to disordered eating behaviors in men, specifically muscle dysmorphia (MD), which is a preoccupation with achieving a muscular ideal.
- A study involving 269 U.S. men examined how these anti-fat attitudes relate to symptoms of MD over time, using multiple surveys spaced a month apart.
- Findings showed that beliefs about fat people lacking willpower were connected to desires for greater muscle size, and struggles with MD symptoms could lead to fears of gaining weight, suggesting treating weight stigma may help alleviate MD issues in male patients.