Evaluating the Impact of Glucagon-Like Peptide-1 Receptor Agonists on Metabolic Changes in Patients With Type 2 Diabetes on High-Dose Insulin.

Background: Studies involving the glucagon-like peptide-1 receptor agonist (GLP-1 RA) liraglutide have shown reductions in hemoglobin A1c (HbA1c), weight, and insulin requirements in patients with type 2 diabetes mellitus (DM2) requiring high-dose insulin therapy. The effect of the class of GLP-1 RAs on these parameters is unknown.

Data Sources: A retrospective cohort analysis was conducted in patients with DM2 where a GLP-1 RA was added to high-dose insulin therapy.

Evidence that moxidectin is a greater risk factor than ivermectin in the development of resistance to macrocyclic lactones by Ostertagia spp in sheep in south eastern Australia.

Aim: To determine associations between resistance of Ostertagia (=Teladorsagia) spp to macrocyclic lactone (ML) anthelmintics and history of use of anthelmintics, by type, on commercial sheep farms in temperate regions of southern South Australia and Victoria, Australia.

Methods: Faecal egg count reduction tests (FECRTs) were conducted during a 2.5-year period (from August 2001 to January 2004) and records of the type of anthelmintic used in the 5 years preceding the FECRTs were collected from commercial sheep farms (n=103) in southern South Australia and Victoria, and data analysed retrospectively.

[Towards a sheltered aging in individual and social responsibility].

Aging is a slow process, the beginning of which as well as its progress are defined in quite different ways from the biomedical, psychological, or sociological point of view. Philosophy can perform a significant contribution to a sound and human approach to this phenomenon of life: first clarifying the present situation on the background of historic experiences; second improving a fundamental ascertainment of our ontological condition as human beings, characterized by finiteness and vulnerability, while recalling that humans possess the unique capability to reflect on this aspect of their existence; and, always moving from the results of that analysis, lastly suggesting some tentative solutions, conceived as ethical-practical guidelines and values pool, for an overcoming of the individual and social challenges posed by aging. The aim consists in a re-interpretation of aging as a "becoming oneself", without denying hereby the negativity embodied in the finiteness and fragility of our life.