Publications by authors named "T E KLYUCHAREVA"
Incubation of gangliosides with natural killer (NK) cells from various sources was found to inhibit NK activity in vitro whereas incubation of the same gangliosides with human or mouse lymphoma cells prior to their exposure to NK effectors resulted in a sharp increase in the NK sensitivity of the tumor cells. These effects depended on the oligosaccharide structure of the gangliosides and on the origin of the NK effector cells. The lysis of YAC cells by mouse splenocytes or of MOLT-4 cells by NK cells isolated from the peripheral blood of Syrian hamsters or humans was inhibited most strongly by pre-incubation of the effector cells with gangliosides GM3 and GD3 which are known to be elevated in the serum of tumor-bearing hosts.
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- The study investigated the safety and immune response of a live poliomyelitis vaccine derived from less harmful strains in Leningrad, tested on over 20,000 children aged 6 months to 14 years.
- The vaccination, administered in various stages, did not result in any serious health issues, and antibodies against the virus were observed to develop and remain elevated for several months post-vaccination.
- Some strains of the vaccine showed increased activity in monkeys after multiple passages through children's intestines, but their neurotropic properties returned to baseline levels over time.