Publications by authors named "T E Gundersen"
Article Synopsis
- Developmental dysplasia of the hip (DDH) affects about 2-3% of newborns and is linked to increased risks of osteoarthritis in young adults, leading to many hip replacements before age 40.
- The study reviewed 73 papers, including 31 focused on single nucleotide polymorphisms (SNPs) in DDH, but found many studies lacked sufficient power to identify significant genetic associations.
- While DDH is known to be hereditary, the research is limited and no definitive genetic risk factors have been identified, indicating a need for further investigations.
Many aging men experience reduced energy and libido related to non-optimal testosterone levels. We conducted a randomized double-blind trial with TrigozimR fenugreek extract to assess impact on plasma and saliva testosterone, and some subjective effects. 95 men (40-80y) completed a 12-week intervention, taking 3 tablets daily with 0 mg (placebo; n = 22), 600 mg (n = 21), 1200 mg (n = 25) and1800 mg (n = 27) fenugreek extract and essential nutrients.
View Article and Find Full Text PDFObjectives: To examine radiologic outcomes at skeletal maturity of sonographically normal, immature, mildly, and severely dysplastic newborn hips.
Methods: During 1988 to 1990, 11 925 newborns were enrolled in a randomized controlled trial examining screening strategies for developmental hip dysplasia. In total, 4469 were invited to clinical and radiologic follow-up 18 years later, of which 1735 had received neonatal ultrasound.
Article Synopsis
- Developmental dysplasia of the hip (DDH) affects 2-3% of infants and is linked to increased risk of osteoarthritis and hip surgeries in younger adults, prompting this study to explore its genetic factors for better diagnosis and management.
- The research utilized data from the Trøndelag Health Study, analyzing over 69,000 individuals and over 8.5 million SNPs to identify genetic associations, specifically focusing on the SNPs rs713162 and rs6577334 near the COL11A1 gene, which has ties to hip disorders.
- Findings suggest a significant link between COL11A1 and DDH, supporting previous research on genetic influences and highlighting the need for further investigations into the condition's causes.