Arcopilins: A New Family of Biofilm Disruptors from the Soil Fungus .

Biofilms represent a key challenge in the treatment of microbial infections; for instance, causes chronic or fatal infections by forming biofilms on medical devices. Herein, the fungus was found to produce a novel family of PKS-NRPS metabolites that are able to disrupt preformed biofilms of . Arcopilins A-F (-), tetramic acids, and arcopilin G (), a 2-pyridone, were elucidated using HR-ESI-MS and one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopy.

Chemoselectivity Inversion of Responsive Metal-Organic Frameworks by Particle Size Tuning in the Micrometer Regime.

Gated adsorption is one of the unique physical properties of flexible metal-organic frameworks with high application potential in selective adsorption and sensing of molecules. Despite recent studies that have provided some guidelines in understanding and designing structural flexibility for controlling gate opening by chemical modification of the secondary building units, currently, there is no established strategy to design a flexible MOF showing selective gated adsorption for a specific guest molecule. In a present contribution it is demonstrated for the first time, that the selectivity in the gate opening of a particular compound can be tuned, changed, and even reversed using particle size engineering DUT-8(Zn) ([Zn(2,6-ndc)(dabco)], 2,6-ndc = 2,6-naphthalenedicarboxylate, dabco = 1,4-diazabicyclo-[2.

Molecular replacement for small-molecule crystal structure determination from X-ray and electron diffraction data with reduced resolution.

The resolution of 3D electron diffraction (ED) data of small-molecule crystals is often relatively poor, due to either electron-beam radiation damage during data collection or poor crystallinity of the material. Direct methods, used as standard for crystal structure determination, are not applicable when the data resolution falls below the commonly accepted limit of 1.2 Å.

Analysis of diffuse scattering in electron diffraction data for the crystal structure determination of Pigment Orange 13, CHClNO.

The crystallographic study of two polymorphs of the industrial pyrazolone Pigment Orange 13 (P.O.13) is reported.

Electron-Beam- and Thermal-Annealing-Induced Structural Transformations in Few-Layer MnPS.

Quasi-two-dimensional (2D) manganese phosphorus trisulfide, MnPS, which exhibits antiferromagnetic ordering, is a particularly interesting material in the context of magnetism in a system with reduced dimensionality and its potential technological applications. Here, we present an experimental and theoretical study on modifying the properties of freestanding MnPS by local structural transformations via electron irradiation in a transmission electron microscope and by thermal annealing under vacuum. In both cases we find that MnSP phases (0 ≤ < 1) form in a crystal structure different from that of the host material, namely that of the α- or γ-MnS type.