Publications by authors named "T E Downing"
Article Synopsis
- Cutaneous leishmaniasis caused by Leishmania tropica is prevalent in the Middle East, with documented cases of treatment failure and drug resistance linked to genetic mechanisms like SNPs and CNVs.
- The study analyzed SNP and CNV patterns in 22 isolates from Afghanistan, Iran, and Syria, revealing a high frequency of SNPs, especially on chromosome 23 in Syrian isolates, and significant changes in CNV related to drug exposure.
- Findings suggest that Leishmania tropica employs various genetic adaptations, including enhanced mechanisms for survival under drug pressure, indicating its resilience and ability to adapt to environmental and therapeutic challenges.
Background: Surveillance for heart transplant rejection by endomyocardial biopsy is invasive and may yield false negatives. T1 and T2 mapping from cardiac magnetic resonance can demonstrate elevations with rejection. We sought to evaluate longitudinal changes in T1 and T2 mapping in pediatric patients with heart transplant.
View Article and Find Full Text PDFThe 3d organization of the genome - in particular, which two regions of DNA are in contact with each other - plays a role in regulating gene expression. Several factors influence genome 3d organization. Nucleosomes (where ~ 100 basepairs of DNA wrap around histone proteins) also bend, twist and compactify chromosomal DNA, altering its polymer mechanics.
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- Neonates with symptomatic tetralogy of Fallot (sTOF) often require early surgical intervention, which can involve either staged repair (SR) or primary repair (PR), but both strategies expose them to low-dose ionizing radiation that may raise cancer risk.
- This study analyzed the cumulative radiation exposure and lifetime attributable risk (LAR) of cancer in sTOF patients who underwent either SR or PR, using data from 242 neonates across multiple centers.
- Results showed that SR resulted in significantly higher radiation exposure compared to PR and highlighted an increased LAR of cancer, particularly for females, emphasizing the need to consider radiation risk when choosing treatment options for this vulnerable group.*
Article Synopsis
- * A survey of 79 program directors revealed notable differences in training pathways and case volumes, with a recommendation for trainees to complete at least 400 total cases, including 250 interventional cases.
- * Ongoing mentorship is essential for mastering complex procedures, and external mentorship programs are suggested to enhance support for new interventionalists and improve patient care in congenital heart disease.