Publications by authors named "T E Bunchman"
Background: Some inborn errors of metabolism (IEMs) resulting in aberrations to blood leucine and ammonia levels are commonly treated with kidney replacement therapy (KRT). Children with IEMs require prompt treatment, as delayed treatment results in increased neurological and developmental morbidity.
Objectives: Our systematic review in neonates and pediatrics evaluates survival rates and reductions in ammonia and leucine levels across different KRT modalities (continuous KRT (CKRT), hemodialysis (HD), peritoneal dialysis (PD)).
Article Synopsis
- Dialysis disequilibrium syndrome (DDS) is a serious but rare complication in patients starting dialysis, particularly those with advanced kidney failure; understanding its causes, patterns, and prevention is crucial.
- A study was conducted on 50 pediatric patients with severe kidney disease, applying a standardized protocol to minimize the risk of DDS during their initial dialysis treatment.
- Results showed a low incidence of DDS (4%) and severe DDS (2%) in the cohort, despite significant urea and creatinine levels, underlining the effectiveness of the preventive measures implemented.
Key Points: Despite a high need and interest in point-of-care ultrasound (POCUS) in trainees and faculty of Pediatric Nephrology, the majority are not receiving POCUS training. There is a need to establish a structured pediatric nephrology POCUS program for clinicians and fellows. This study suggests a blueprint of POCUS curriculum which can serve as a foundation for POCUS education in pediatric nephrology centers worldwide.
View Article and Find Full Text PDFExtracorporeal membrane oxygenation (ECMO) provides temporary cardiorespiratory support for neonatal, pediatric, and adult patients when traditional management has failed. This lifesaving therapy has intrinsic risks, including the development of a robust inflammatory response, acute kidney injury (AKI), fluid overload (FO), and blood loss via consumption and coagulopathy. Continuous kidney replacement therapy (CKRT) has been proposed to reduce these side effects by mitigating the host inflammatory response and controlling FO, improving outcomes in patients requiring ECMO.
View Article and Find Full Text PDFArticle Synopsis
- Focal segmental glomerular sclerosis (FSGS) is a leading cause of nephrotic syndrome that can lead to end-stage kidney disease and is known to recur after kidney transplants, increasing the risk of graft loss and patient complications.* -
- A research group conducted a comprehensive review of existing literature to establish guidelines focused on the causes, risk factors, and management strategies for recurrent FSGS, examining 614 studies and narrowing it down to 221 relevant ones.* -
- The resulting recommendations indicate the need for further studies to enhance and solidify the guidelines for managing recurrent FSGS in transplant patients.*