The normal range and the decision interval.

The concept of the decision interval which replaces the normal range in medical decision-making in the contemporary setting of evidence- and procedure-based medicine is presented. The definition and some properties of the decision interval are discussed.

Significance of Haemodynamic and Haemostatic Factors in the Course of Different Manifestations of Cerebral Small Vessel Disease: The SHEF-CSVD Study-Study Rationale and Protocol.

Rationale. This paper describes the rationale and design of the SHEF-CSVD Study, which aims to determine the long-term clinical and radiological course of cerebral small vessel disease (CSVD) and to evaluate haemostatic and haemodynamic prognostic factors of the condition. Design.

Indicator-based assessment of environmental hazards and health effects in the industrial cities of upper Silesia, Poland.

Using an indicator-based approach, we assessed environmental hazards and related health effects in populations of industrial cities with more than 100,000 inhabitants in Upper Silesia, Poland, and analyzed the relationship between environment and health. We adopted the method developed by Dutkiewicz et al. for assessing large geographic areas.

Percutaneous absorption studies after forty years.

The authors review the development of ways to study percuatneous absorption of chemicals and summarize the current status of investigations in this area.