Publications by authors named "T Duncan"
Artificial water channels (AWCs) have emerged as a promising framework for stable water permeation, with water transport rates comparable to aquaporins (3.4-40.3 × 10 HO/channel/s).
View Article and Find Full Text PDFWith the increasing age of the population in the USA, fall prevention events to target older patients are imperative. The American Association for the Surgery of Trauma hosted a fall prevention event at the host city of the 2023 Annual Meeting. We review the planning and implementation of this "Stop the Falls" event, in hopes that other institutions may benefit and sustainably effectuate fall prevention events for an increasingly geriatric population.
View Article and Find Full Text PDFAnion Selectivities in Zwitterion Grafted Nanopores: Effect of Zwitterion Architecture.
ACS Appl Mater Interfaces
October 2024
Article Synopsis
- - The study focuses on the separation of similar-charge ions and explores membranes made from zwitterionic amphiphilic copolymers (ZAC-X) that can selectively allow the passage of different anions, particularly comparing two structural arrangements, Motif A and Motif B.
- - Molecular dynamics simulations were used to analyze how the orientation of zwitterionic ligands affects the movement and selectivity of anions, revealing that Motif A shows less ion pairing while Motif B demonstrates stronger pairing for small anions.
- - Results indicate that the size of anions influences their partitioning and diffusivity, with Motif B showing higher selectivity for larger anions; ultimately, partitioning trends have a greater impact on
Article Synopsis
- The study examines the impact of illicit substance use during pregnancy, noting a 4-fold increase over two decades and its negative effects on mothers and fetuses.
- A multicenter retrospective analysis from 2016 to 2021 included 852 pregnant trauma patients (PTPs), with 9.8% testing positive for substances, primarily THC and methamphetamine.
- Findings showed that PTPs with positive urine toxicology had higher rates of blunt head injuries, extremity injuries, domestic violence incidents, and uterine contractions, but similar maternal complication rates compared to those who tested negative.
ATP synthase of E. coli: F-ATPase activity is functionally decoupled from the proton-transporting complex (F) by tributyltin.
Biochem Biophys Res Commun
November 2024
The F-type ATP synthase/ATPase (FF) is important for cellular bioenergetics in eukaryotes and bacteria. We recently showed that venturicidins, a class of macrolides that inhibit the proton transporting complex (F), can also induce time-dependent functional decoupling of F-ATPase from F on membranes from Escherichia coli and Pseudomonas aeruginosa. This dysregulated ATPase activity could deplete bacterial ATP levels and contribute to venturicidin's capacity to enhance the bactericidal action of aminoglycosides antibiotics.
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