Publications by authors named "T Dowswell"
Article Synopsis
- Ivermectin, originally an antiparasitic drug, has been tested in multiple clinical trials for its potential to reduce mortality and prevent COVID-19 infection due to its antiviral and anti-inflammatory properties.
- Meta-analysis of 15 trials indicated that ivermectin significantly lowered the risk of death among COVID-19 patients and showed promise in reducing infection rates, although the evidence for some secondary outcomes was less certain.
- Overall, while moderate evidence supports ivermectin's efficacy in reducing COVID-19-related mortality, findings on its effectiveness for other outcomes remain inconclusive, highlighting the need for further research.
Interventions to reduce the time to diagnosis of brain tumours.
Cochrane Database Syst Rev
September 2020
Article Synopsis
- - Brain tumors are challenging to diagnose due to nonspecific symptoms like headaches and seizures that can be linked to less serious conditions, leading to delays in detection and treatment.
- - The objectives of the study are to evaluate the effectiveness of various interventions aimed at shortening the time it takes for patients to seek help and receive a diagnosis for brain tumors, along with an economic analysis of these interventions.
- - The researchers conducted a comprehensive literature search for relevant studies on diagnostic interventions and their economic impact from various databases and timeframes to gather data for their evaluation.
Background: Multiple pregnancy is a strong risk factor for preterm birth, and more than 50% of women with a twin pregnancy will give birth prior to 37 weeks' gestation. Infants born preterm are recognised to be at increased risk of many adverse health outcomes, contributing to more than half of overall perinatal mortality. Progesterone is produced naturally in the body and has a role in maintaining pregnancy, although it is not clear whether administering progestogens to women with multiple pregnancy at high risk of early birth is effective and safe.
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- The World Health Organization (WHO) has implemented a 'living guidelines' approach to continuously update its maternal and perinatal health (MPH) recommendations.
- This method involves systematic prioritization and regular updates, ensuring that new evidence is rapidly incorporated.
- As a result, between 2017 and 2018, WHO published 25 new or updated MPH recommendations, maintaining relevance for healthcare providers and users.
Article Synopsis
- Gliomas are brain tumors from glial cells, with low-grade gliomas being less aggressive, typically treated with surgery and possibly followed by radiotherapy, raising concerns about long-term neurocognitive effects.
- This review aims to assess the long-term neurocognitive side effects of radiotherapy (with/without chemotherapy) versus no treatment or alternative types of radiotherapy in glioma patients, defining “long-term” as at least two years post-diagnosis.
- The authors conducted a comprehensive search for relevant studies, including nine studies with a total of 2406 participants, focusing on those aged 16 and older with cerebral gliomas (excluding glioblastoma) and assessed the quality of the findings using the GRADE approach.