Publications by authors named "T Downes"
Article Synopsis
- * The article introduces a new method called top-down drug discovery (TD), which involves searching through a large database of fungi to find genetic locations that produce molecules targeting specific human proteins, like cyclin-dependent kinases (CDKs).
- * Researchers successfully discovered two new molecules that inhibit CDKs and improved one of them to enhance its selectivity and effectiveness, showcasing the potential of TD for developing innovative medicines.
Understanding Effects of Visual Feedback Delay in AR on Fine Motor Surgical Tasks.
IEEE Trans Vis Comput Graph
November 2023
Latency is a pervasive issue in various systems that can significantly impact motor performance and user perception. In medical settings, latency can hinder surgeons' ability to quickly correct movements, resulting in an experience that doesn't align with user expectations and standards of care. Despite numerous studies reporting on the negative effects of latency, there is still a gap in understanding how it impacts the use of augmented reality (AR) in medical settings.
View Article and Find Full Text PDFCOVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting points for such therapeutics, we performed a large-scale screen of electrophile and non-covalent fragments through a combined mass spectrometry and X-ray approach against the SARS-CoV-2 main protease, one of two cysteine viral proteases essential for viral replication.
View Article and Find Full Text PDFWe present our current best estimate of the plausible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next several years, with the intention of providing information to facilitate planning for multi-messenger astronomy with gravitational waves. We estimate the sensitivity of the network to transient gravitational-wave signals for the third (O3), fourth (O4) and fifth observing (O5) runs, including the planned upgrades of the Advanced LIGO and Advanced Virgo detectors. We study the capability of the network to determine the sky location of the source for gravitational-wave signals from the inspiral of binary systems of compact objects, that is binary neutron star, neutron star-black hole, and binary black hole systems.
View Article and Find Full Text PDFArticle Synopsis
- On May 21, 2019, Advanced LIGO and Virgo detected a significant gravitational-wave signal known as GW190521, indicating a high probability event with a low chance of false alarms.
- The signal suggests it resulted from the merger of two black holes, one around 85 solar masses and the other about 66 solar masses, with the primary black hole likely being an intermediate mass black hole.
- The source of the merger is estimated to be about 5.3 billion light-years away, and the rate of similar black hole mergers is estimated to be about 0.13 mergers per billion cubic parsecs per year.