Two-year toxicity/carcinogenicity study of fresh-brewed coffee in rats initially exposed in utero.

Fresh-brewed regular coffee at concentrations of 25, 50, and 100% was consumed ad libitum as the sole fluid intake of F1 Sprague-Dawley rats (55 male and 55 female/group), derived from P0-treated females which were provided 50% coffee for about 5 weeks prior to copulation and throughout gestation and lactation. P0 males, P0 control females, and two groups of F1 control rats received tap water. Ten rats/sex/level were killed and examined after 1 year; survivors were killed after 2 years.

Health of experimental animals drinking water with and without amosite asbestos and other mineral particles.

In view of diseases associated with inhalation of asbestos fibers, interest attaches to the question of whether risks are presented by ingestion of asbestos or mineralogically related fibrous-shaped particles reported in drinking water supplies. Experimental animals (hamsters) were maintained on filtered drinking water with and without addition of mineral particles. A peritoneal mesothelioma, pulmonary carcinoma and two early squamous cell carcinomas of the forestomach were found in hamsters so exposed to a preparation of amosite asbestos.