Publications by authors named "T Dinan"
Pain and psychological stress are intricately linked, with sex differences evident in disorders associated with both systems. Glutamatergic signalling in the central nervous system is influenced by gonadal hormones via the hypothalamic-pituitary-adrenal axis and is central in pain research. Emerging evidence supports an important role for the gut microbiota in influencing pain signalling.
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- This review explores how antidepressants affect gut microbiota composition and function, suggesting that gut bacteria may influence how well antidepressants work.
- Antidepressant users typically show increased β-diversity and notable changes in specific gut bacteria, such as higher levels of Bacteroidetes and decreases in Firmicutes.
- The study also identifies potential biomarkers, like certain gut bacteria populations, that could predict response to antidepressant treatment, emphasizing the necessity for more research to better understand these interactions.
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- Early life stress, like maternal separation in rats, impacts gut-brain communication and the microbiota, affecting later risk for stress-induced disorders differently in males and females.
- The research involved analyzing fecal samples and assessing changes in pain sensitivity and behavior in adulthood, revealing four distinct clusters: resilient, pain, immobile, and comorbid, each with unique gut microbiota profiles.
- This study highlights how early gut microbiota changes can define adult behavioral responses, marking a step forward in understanding the relationship between gut health and stress resilience or susceptibility.
Social anxiety disorder is a common psychiatric condition that severely affects quality of life of individuals and is a significant societal burden. Although many risk factors for social anxiety exist, it is currently unknown how social fear sensitivity manifests biologically. Furthermore, since some individuals are resilient and others are susceptible to social fear, it is important to interrogate the mechanisms underpinning individual response to social fear situations.
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