Publications by authors named "T Dill"

Article Synopsis
  • * This study introduces a novel PROTAC called StIP-TAC, which recruits E3 ligase to Protein Kinase A (PKA) using a hydrocarbon-stapled peptide, effectively promoting the degradation of PKA.
  • * Treatment with StIP-TAC not only induced the degradation of PKA but also significantly reduced its activity by lowering phosphorylation of its substrates, suggesting that this approach can potentially target a wider range of proteins lacking suitable small molecule binding sites.
View Article and Find Full Text PDF

Background: Assessing trainees is crucial for development of their competence, yet it remains a challenging endeavour. Identifying contributing and influencing factors affecting this process is imperative for improvement.

Methods: We surveyed residents, fellows, and intensivists working in an intensive care unit (ICU) at a large non-university hospital in Switzerland to investigate the challenges in assessing ICU trainees.

View Article and Find Full Text PDF

Background: For patients with acute myocardial infarction (AMI), direct coronary angiography (CA) is recommended, while for non-AMI patients, the diagnostic work-up depends on clinical criteria. This analysis provides initial prospective German data for the degree of guideline-adherence (GL) in the use of CA on non-AMI patients presenting at the emergency department (ED) with suspected acute coronary syndrome (ACS) according to the 2015 ESC-ACS-GL. Furthermore the implications of the application of the 2020 ESC-ACS-GL recommendations were evaluated.

View Article and Find Full Text PDF

Rescue treatments for status asthmaticus remain limited. Current literature has mainly focused on using extracorporeal membrane oxygenation (ECMO) as a primary modality of care for these patients. Low-flow extracorporeal CO 2 removal (ECCO 2 R) systems are an attractive option to improve refractory hypercapnic respiratory acidosis because of status asthmaticus.

View Article and Find Full Text PDF