Severe Bartter syndrome type 1: Prompt postnatal management thanks to antenatal identification of SLC12A1 pathogenic variants.

Bartter syndrome (BS) refers to a group of hereditary kidney disorders. One antenatal form is Bartter syndrome type 1 (BS1), caused by pathogenic variants in the SLC12A1 gene. We report a case of BS1 presenting with severe polyhydramnios.

Metastatic pancreatic cancer in late pregnancy: a case report and review of the literature.

The occurrence of pancreatic carcinoma in a young patient is rare and even more so in pregnancy. In this case report, we discuss the presentation and management of pancreatic adenocarcinoma, with lung and liver metastases, diagnosed in a woman in her third trimester of pregnancy (28 weeks). Ultrasound and magnetic resonance imaging scans were carried out and pancreatic mass biopsy during endoscopic retrograde cholangiopancreatography was performed.

Adrenomedullin in human male reproductive system.

Objective: To investigate adrenomedullin (AM) localization and distribution in human male reproductive system and to determine whether seminal fluid AM concentration correlates with sperm parameters.

Study Design: Plasma and semen samples (n = 19) obtained from healthy volunteers with normal seminal fluid parameters were assayed for AM using a specific RIA. AM immunostaining was sought on sections of penile cavernous bodies and testicular tissues obtained postmortem from four young males after accidental death using a polyclonal antibody to AM 1-52.

Adrenomedullin and nitric oxide synthase at the maternal-decidual interface in early spontaneous abortion.

Objective: To investigate local and systemic nitric oxide (NO) and adrenomedullin (AM) production in spontaneous abortion.

Study Design: Plasma samples and placental specimens were collected from 25 women with spontaneous abortion (6-12 weeks of gestation) and 25 women who underwent voluntary pregnancy termination. NO and AM levels were assayed in plasma; placental NO isoenzymes (inducible NOS and endothelial NOS) and AM distribution and localization were determined by immunohistochemistry.