Publications by authors named "T Denning"
Article Synopsis
- The study highlights the success of mRNA lipid nanoparticle (LNP) vaccines in quickly addressing urgent vaccine needs, but notes their limitations in generating mucosal responses and broad protection against variants.
- Researchers engineered an advanced mRNA LNP vaccine that includes a novel cytokine adjuvant and influenza A antigen, resulting in strong antibody and T cell responses in mice.
- Two different adjuvants, GIFT4 and CCL27, were shown to effectively enhance both humoral and cellular immune responses, indicating the potential of cytokine mRNA as a versatile component in mRNA vaccine formulations for improved immunity against viruses.
Article Synopsis
- Influenza infections pose a serious threat to global health, prompting the need for improved vaccine formulations due to current vaccines inadequately protecting against circulating strains.
- Researchers developed a novel intranasal vaccine using protein nanoparticles made of influenza proteins and a bacterial component, which enhanced immune responses in mice.
- This innovative slow-delivery vaccination method significantly boosted immune responses and survival rates against different strains of the virus, suggesting its potential effectiveness in addressing influenza outbreaks.
Intestinal mucins play an essential role in the defense against bacterial invasion and the maintenance of gut microbiota, which is instrumental in the regulation of host immune systems; hence, its dysregulation is a hallmark of metabolic disease and intestinal inflammation. However, the mechanism by which intestinal mucins control the gut microbiota as well as disease phenotypes remains nebulous. Herein, we report that N-acetylglucosamine (GlcNAc)-6-O sulfation of O-glycans on intestinal mucins performs a protective role against obesity and intestinal inflammation.
View Article and Find Full Text PDFInflammatory bowel disease (IBD) is a multifactorial, chronic disease that affects approximately 1.5 million people in the United States [1]. It presents with inflammation of the intestine with unknown etiology and its two main forms are Crohn's disease (CD) and ulcerative colitis (UC).
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