Publications by authors named "T Demura"
: Restoration of the mandibular region after segmental resection surgery is crucial for masticatory function and facial aesthetics. The precision of three-dimensional printers has advanced in recent years, enabling the development of fully customized reconstruction plates. In recent years, three-dimensional printing technology has been applied in the field of dental and oral surgery.
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- Lung cancer is a major global health issue, influenced by cancer stem cells (CSCs), but the interaction between these CSCs and SARS-CoV2 is not well understood.
- This study compares lung adenocarcinoma samples from 12 patients who had COVID-19 with 12 who did not, examining tumor characteristics and CSC markers.
- Results indicated that patients who had COVID-19 had significantly more CSCs (marked by ALDH1, CD133, and CD34) in their tumors, suggesting that COVID-19 may enhance the metastatic potential of lung adenocarcinoma and the presence of viral proteins in the lung tissue.
Lymphovascular invasion (LVI) in lung cancer is a significant prognostic factor that influences treatment and outcomes, yet its reliable detection is challenging due to interobserver variability. This study aims to develop a deep learning model for LVI detection using whole slide images (WSIs) and evaluate its effectiveness within a pathologist's information system. Experienced pathologists annotated blood vessels and invading tumor cells in 162 WSIs of non-mucinous lung adenocarcinoma sourced from two external and one internal datasets.
View Article and Find Full Text PDFNoninvasive, rapid, and robust diagnostic techniques for clinical screening of tumors located in arbitrary areas of the human body are in demand. To address this challenge, we analyzed the feasibility of photoplethysmography-based angiography for assessing vascular structures within malignant and benign tumors. The proposed hardware and software were approved in a clinical study involving 30 patients with tumors located in the legs, torso, arms, and head.
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- * Anthracyclines, particularly doxorubicin, are effective in fighting tumors but can cause serious heart damage, known as cardiotoxicity.
- * Understanding how doxorubicin affects heart function is essential for creating new protective strategies against its harmful impacts on the cardiovascular system.