Publications by authors named "T Deis"
Heart failure (HF) is a syndrome affecting all organ systems. While some organ interactions have been studied intensively in HF (such as the cardiorenal interaction), the endocrine gut has to some degree been overlooked. However, there is growing evidence of direct cardiac effects of several hormones secreted from the gastrointestinal tract.
View Article and Find Full Text PDFReductive C(sp)-Si Cross-Couplings by Catalytic Sodium-Bromine Exchange.
Angew Chem Int Ed Engl
October 2024
The metal-halogen exchange reaction constitutes one of the most important preparative routes towards polar organometallic reagents such as aryllithium or Grignard reagents. However, despite extensive developments over the past eight decades, this fundamental organometallic elementary step has only been exploited stoichiometrically. Against this background, we demonstrate that the sodium-bromine exchange reaction can be implemented in a catalytic setting as a mean to activate C(sp)-Br bonds in a transition metal-free manner en route to the regioselective and general preparation of (hetero)aryl silanes.
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- Socioeconomic status (SES) impacts heart failure prognosis and access to advanced evaluation, with lower SES often linked to worse outcomes.
- A study analyzed data from 631 heart failure patients to assess the relationship between SES factors (like income and education) and invasive haemodynamics.
- Results showed higher household income correlated with lower pulmonary capillary wedge pressure, but notable differences in cardiac index and pulmonary vascular resistance between the most and least deprived groups were observed, suggesting complex interactions between SES and heart function.
Article Synopsis
- Pleural effusion is common in patients with acute heart failure, affecting 50% to 80% of cases, and is linked to central hemodynamics like pulmonary capillary wedge pressure (PCWP).
- This study involved 346 patients with advanced heart failure, identifying pleural effusion in 47%, with larger effusions correlating with higher filling pressures.
- The research found that higher PCWP and central venous pressure were significantly associated with the presence and size of pleural effusion, along with serum albumin levels, highlighting potential markers for evaluating heart failure severity.
Background: Socioeconomic deprivation is associated with a lower likelihood of referral for advanced heart failure (HF) evaluation, but it is not known whether it influences rates of advanced HF therapies independently of key hemodynamic measures and comorbidity following advanced HF evaluation in a universal healthcare system.
Methods: We linked data from a single-center Danish clinical registry of consecutive patients evaluated for advanced HF with patient-level information on socioeconomic status. Patients were divided into groups based on the level of education (low, medium, and high), combined degree of socioeconomic deprivation (low, medium, and high), and household income quartiles.