Publications by authors named "T De Kock"
Control of Bilayer Transport through a Photoswitchable Membrane-Stiffening Agent.
Angew Chem Int Ed Engl
December 2024
The mobility of proteins in the bilayer membrane is affected by (local) changes in lipid environment, which is important to their biological functioning. Artificial molecular systems that-to some extent-imitate tasks of membrane-embedded proteins are increasingly developed, however, they are usually controlled through responsive units in their core structure. Here we present an alternative approach based on an amphiphilic stiff-stilbene derivative that enables control of membrane fluidity by light.
View Article and Find Full Text PDFBackground: Sex- and population-specific 99th percentiles of high-sensitivity cardiac troponin (hs-cTn) are recommended in guidelines although the evidence for a clinical utility is sparse. The DANSPOT trial will investigate the clinical effect of sex- and population-specific 99th percentiles of cTn. We report the 99th percentiles derived from this trial and their dependency on kidney function.
View Article and Find Full Text PDFBackground: Left ventricular noncompaction (LVNC) is characterized by excessive trabeculations of the left ventricular (LV) wall.
Objectives: The authors aimed to examine changes in LV function and morphology in 2 to 4-year-old children with and without LVNC at birth and to describe the prevalence of LVNC in first-degree relatives.
Methods: Echocardiograms in children with and without LVNC (matched 1:4) were performed at 2 to 4 years and in first-degree relatives.
Lipid conjugates have advanced the field of lipid-based nanomedicine by promoting active-targeting (ligand, peptide, antibody), stability (PEGylation), controlled release (lipoid prodrug), and probe-based tracking (fluorophore). Recent findings indicate lipid conjugates dissociating from nanomedicine upon encountering a biological environment. Yet, implications for (pre)clinical outcomes remain unclear.
View Article and Find Full Text PDFArticle Synopsis
- This study examines how different relative humidity (RH) levels affect the crystallization of salt mixtures, which is important for fields like building preservation and geology.
- The researchers used various methods, including time-lapse imaging and microstructural analysis, to observe how composition and RH rates influence crystallization and dissolution behaviors.
- Findings indicate that rapid and slow humidity changes significantly impact salt phase transitions, leading to deviations from predicted models, which could inform better preservation techniques and understanding of geological processes.