Publications by authors named "T De Haas"
Background: With the approval of disease-modifying treatments for 5q-spinal muscular atrophy (SMA), there is an increasing need for biomarkers for disease course and therapeutic response monitoring. Radially sampled Averaged Magnetization Inversion Recovery Acquisitions (rAMIRA) MR-imaging enables spinal cord (SC) gray matter (GM) delineation and quantification in vivo. This study aims to assess SC GM atrophy in patients with 5q-SMA and its associations with clinical disability.
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- The paper presents a method to linearize the nonlinear behaviors of flow control valves by designing a variable gear ratio.
- It derives the relationship between the valve's capacity coefficients and its opening percentage from flow experiments, revealing that the gear ratio influences the valve's performance.
- Experimental results show that the approach successfully achieves linearized flow characteristics, with a very high correlation (R-squared = 0.9984) to expected outcomes.
Adoptive immunotherapy with T cells, genetically modified to express a tumor-reactive chimeric antigen receptor (CAR), is an innovative and rapidly developing life-saving treatment for cancer patients without other therapeutic opportunities. CAR-T cell therapy has proven effective only in hematological malignancies. However, although by now only a few clinical trials had promising outcomes, we predict that CAR-T therapy will eventually become an established treatment for several solid tumors.
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- * New ways to check for bleeding issues are being developed, like viscoelastic testing, but there aren’t enough age-specific guidelines for doctors to follow yet.
- * Treatment for children with bleeding problems can include medications and blood products, and doctors are advised to use expert opinions until more research is done on how to best manage these situations in kids.
Background: Intraoperative hemorrhage in cardiac surgery increases risk of morbidity and mortality. Low pre-operative and perioperative levels of fibrinogen, a key clotting factor, are associated with severity of hemorrhage and increased transfusion of blood components. The ability to supplement fibrinogen during hemorrhagic resuscitation is delayed 45-60 min because cryoprecipitated antihemophilic factor (cryo AHF) is stored frozen, due to a short post-thaw shelf life.
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