Publications by authors named "T Damodaran"
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disorder where anti-RNP antibodies show unique gene expression and immune responses, prompting a study of gene profiles in affected patients.
- The study analyzed gene expression data from 79 anti-RNP-positive SLE patients and 30 healthy controls, identifying 1891 differentially expressed genes (DEGs) and conducting various enrichment analyses to understand immune tissue involvement.
- Results indicated significant dysregulation in antiviral and immune regulation pathways in anti-RNP-positive patients, suggesting a distinct immune profile influenced by altered gene expression, which provides valuable insights into their condition.
An innovative tissue culture mediated incorporation of metabolite-based biomolecule (Bio-immune) at stage itself in banana cv. Grand Naine was developed and validated for the production of f.sp.
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- * The study explored how using crop residue in conservation tillage improves zinc uptake in rice and wheat grown in reclaimed sodic soil.
- * Results showed that planting techniques that retain crop residue significantly enhance zinc intake, suggesting strategies for better nutritional security and reduced environmental harm from crop burning.
In this narrative review, we present the evidence on nucleotide-binding and oligomerization (NOD) domain-like receptor (NLR) family pyrin domain (PYD)-containing 3 (NLRP3) inflammasome activation for its putative roles in the elusive pathomechanism of aging-related cerebral small vessel disease (CSVD). Although NLRP3 inflammasome-interleukin (IL)-1β has been implicated in the pathophysiology of coronary artery disease, its roles in cerebral arteriothrombotic micro-circulation disease such as CSVD remains unexplored. Here, we elaborate on the current manifestations of CSVD and its' complex pathogenesis and relate the array of activators and aberrant activation involving NLRP3 inflammasome with this condition.
View Article and Find Full Text PDFKratom ( Korth), a popular opioid-like plant holds its therapeutic potential in pain management and opioid dependence. However, there are growing concerns about the safety or potential toxicity risk of kratom after prolonged use. The study aimed to assess the possible toxic effects of kratom decoction and its major alkaloids, mitragynine, and speciociliatine in comparison to morphine in an embryonic zebrafish model.
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