Publications by authors named "T Daboval"
Background: Umbilical artery gas results help obstetricians assess fetal well-being during labor and guide screening decisions on eligibility for therapeutic hypothermia (ie, whole-body or head cooling). The accuracy of results, especially for the base deficit on arterial cord gas analysis, in predicting brain injury is questioned. A novel biomarker specifically calculated for fetal acid-base physiology and response to asphyxia-neonatal eucapnic pH as a marker of neonatal metabolic acidosis-has the potential to be an accurate predictor of hypoxic-ischemic encephalopathy.
View Article and Find Full Text PDFIs it time to end the use of base deficit for fetal well-being assessment?
Am J Obstet Gynecol
September 2024
Article Synopsis
- Authors are concerned about using base deficit measurements from umbilical artery blood samples to evaluate fetal well-being during labor and predict neonatal health issues.
- Both whole blood and extracellular fluid classifications of base deficit rely on normal adult acid-base characteristics, ignoring the specific in utero conditions that exist during fetal development.
- Misinterpretation of these measurements can lead to inaccurate assessments, potentially affecting clinical decisions related to fetal heart rate monitoring and neonatal outcomes.
Objective: To consider the classical use of "pH < 7.0 and/or a base deficiency ≥12 mmol/L" as markers of the risk of neonatal hypoxic-ischemic encephalopathy (HIE), recalling various criticisms of the use of these markers in favor of that of neonatal eucapnic pH, which appears to be a better marker of this risk.
Methods: Fifty-five cases of acidemia with pH < 7.
Article Synopsis
- Transient tachypnea of the newborn (TTN) is a common cause of respiratory distress in infants, and salbutamol, a β2-adrenergic receptor agonist, may help improve alveolar fluid absorption and prevent persistent pulmonary hypertension (PPHN).
- A multicenter, double-blind, phase III trial will assess the effectiveness and safety of nebulized salbutamol combined with non-invasive ventilation in treating TTN in infants, involving 608 participants from neonatal intensive care units in Poland.
- The study aims to measure the incidence of PPHN among TTN infants as the main outcome, alongside various secondary outcomes related to respiratory distress severity and overall health metrics.
Importance: Cerebral palsy (CP) is the most common abnormality of motor development and causes lifelong impairment. Early diagnosis and therapy can improve outcomes, but early identification of infants at risk remains challenging.
Objective: To develop a CP prognostic tool that can be applied to all term neonates to identify those at increased risk of developing CP.