Publications by authors named "T D Sharkey"

We honor Professor Hartmut Karl Lichtenthaler, a versatile pioneer of photosynthesis research, plant physiology, isoprenoid biochemistry, and stress physiology of plants, for his groundbreaking and creative contributions to plant science. His innovative research on the chemical composition, ultrastructure, and function of chloroplasts and his detection of the major methylerythritol 4-phosphate (MEP) isoprenoid biosynthetic pathway in plants is key to our current understanding of the physiology and biochemistry of photosynthesis systems. His ingenious use of the powerful laser-induced chlorophyll fluorescence imaging has helped us better understand the stress response processes in plant leaves.

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Voluntary medical male circumcision (VMMC) is a recommended HIV prevention strategy that few studies have promoted to HIV-negative men in serodiscordant relationships. We conducted a cross-sectional study on uptake and perceptions of VMMC among serodiscordant couples between 2012 and 2015. Heterosexual couples attending couples voluntary counselling and testing for HIV who had discordant results (M-, F+) were referred for VMMC.

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Article Synopsis
  • Rubisco, an enzyme involved in photosynthesis, produces pyruvate in chloroplasts, which is essential for the synthesis of isoprenoids, fatty acids, and branched-chain amino acids.
  • Research indicates that under low oxygen conditions, Rubisco's activity increases, leading to more pyruvate production and enhanced flow through the MEP pathway for isoprenoid biosynthesis.
  • The study reveals that Rubisco is the primary source of pyruvate in chloroplasts and helps clarify its role in the plant's carbon metabolism, thereby addressing the "pyruvate paradox" and improving metabolic model accuracy.
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Isoprene, a volatile hydrocarbon, is typically emitted from the leaves of many plant species. Given its well-known function in plant growth and defense aboveground, we examined its effects on root physiology. We used isoprene-emitting (IE) lines and a non-emitting (NE) line of Arabidopsis and investigated their performance by analyzing root phenotype, hormone levels, transcriptome, and metabolite profiles under both normal and salt stress conditions.

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Opioid misuse continues to cause significant harm. To investigate current research, we conducted a scoping literature review of disease spread models of opioid misuse from January 2000 to December 2022. In total, 85 studies were identified and examined for the opioids modeled, model type, data sources used and model calibration and validation.

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