Item Response Theory Analysis and Differential Item Functioning of the Social Appearance Anxiety Scale.

This study examined the item- and scale-level functioning of the Social Appearance Anxiety Scale (SAAS) as well as differential functioning by gender using an item response theory (IRT) analysis. SAAS data collected from 840 college students were analyzed. A graded response model was used to analyze the 16 items comprising the SAAS.

Derivatives of D(-)-glutamine-based MMP-2 inhibitors as an effective remedy for the management of chronic myeloid leukemia-Part-III: Synthesis, biological screening and in silico binding interaction analysis.

Tyrosine kinase inhibitors (TKIs) have markedly improved the overall survival rate of patients with chronic myeloid leukemia (CML), enabling them to achieve a normal life expectancy. However, toxicity, relapse, and drug resistance continue to pose major challenges in the clinical treatment of CML. The progression of leukemia is directly connected to higher expression levels and enzymatic actions of matrix metalloproteinase-2 (MMP-2).

Integrating the metabolic and molecular circuits in diabetes, obesity and cancer: a comprehensive review.

The progressive globalization of sedentary lifestyles and diets rich in lipids and processed foods has caused two major public health hazards-diabetes and obesity. The strong interlink between obesity and type 2 diabetes mellitus and their combined burden encompass them into a single term 'Diabesity'. They have also been tagged as the drivers for the onset of cancer.

Variables Affecting the Histological Quality of Prostate Core Biopsy Samples in Cancer Detection.

The examination of the prostate biopsy procedure is essential in the optimization of the diagnostic pathway of such a prevalent affliction as prostate cancer among men worldwide. With the core needle biopsy being the standard of care for the diagnosis of prostate cancer, the ability to obtain quality core samples is directly related to patient treatment and diagnostic reliability. Needle deflection and dynamic tissue deformation are two chief sources of unrepresentative samples outside of human error.