Publications by authors named "T D Olver"
Gestational physical activity alters offspring brain APP processing in an age-specific manner.
Appl Physiol Nutr Metab
November 2024
Maternal exercise is beneficial for offspring brain development. Amyloid precursor protein (APP) influences neurogenesis and synaptic plasticity. Cleavage products of APP are implicated in the proliferation of neural progenitor cells and neuronal network development.
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- Exposure to industrial contaminants can negatively impact memory and brain function in rats.
- The study found that rats exposed to contaminated groundwater showed impaired memory but no issues with motor skills.
- A reduction in blood flow to the brain and lower serotonin levels were observed in the contaminated group, suggesting neurotoxic effects, but the specific harmful chemicals remain unidentified.
Congenital heart disease (CHD) is one of today's leading birth anomalies. Children with CHD are at risk for adaptive functioning challenges. Sleep difficulties are also common in children with CHD.
View Article and Find Full Text PDFPatients with heart failure with reduced ejection fraction (HFrEF) have exaggerated sympathoexcitation and impaired peripheral vascular conductance. Evidence demonstrating consequent impaired functional sympatholysis is limited in HFrEF. This study aimed to determine the magnitude of reduced limb vascular conductance during sympathoexcitation and whether functional sympatholysis would abolish such reductions in HFrEF.
View Article and Find Full Text PDFBrain atrophy, reduced cerebral perfusion, arterial stiffening, and wall thickening with aging coincide with stimulus-specific changes in fMRI-BOLD responses.
Am J Physiol Regul Integr Comp Physiol
May 2024
Article Synopsis
- The study looked into how getting older affects blood flow and the structure of the brain.
- Researchers thought that older people would have less gray matter and lower blood flow in the brain compared to younger people.
- They found that while older people had lower blood flow and less gray matter, their brain still activated normally during memory tasks, suggesting that aging affects blood flow but not memory ability in the same way.