[Results of Russian multicenter trial of immunogenicity, reactogenicity and safety of new combination vaccine against hepatitis A and B (Twinrix)].

Results of registration trial of combination vaccine for prevention of hepatitis A and B are presented. The trial was conducted in 5 centers of Russia in 2004-2005 with full accordance to good clinical practice requirements and standards for multicenter open randomized trials. Immunogenicity of studied combination vaccine Twinrix was evaluated in comparison with two simultaneously administered monovalent vaccines against hepatitis A and B (Havrix and Engerix-B) in 200 healthy subjects aged 18-40, which were seronegative to hepatitis A and B.

[Changes in the lymphoid tissue and metabolic shifts in the liver in thymus hormone deficiency].

The investigation has been performed on 44 Wistar rats, some of them at the age of 2 months have been subjected to thymectomy. In 3, 6 and 12 months in the spleen, axillary and popliteal lymph nodes density of cell populations, position of lymphatic nodules have been determined, and in the liver--activity of key enzymes of gluconeogenesis. In the animals with the deficiency of the thymic hormones the most manifested changes are seen in 3 and 12 months: decrease in cell population density in the lymph nodes and in their T-dependent zones, decrease in amount of small lymphocytes, in density of the lymphoid nodules arrangement.