Publications by authors named "T D Mathews"
Reduced nicotinamide adenine dinucleotide phosphate (NADPH) is a crucial reducing cofactor for reductive biosynthesis and protection from oxidative stress. To fulfill their heightened anabolic and reductive power demands, cancer cells must boost their NADPH production. Progrowth and mitogenic protein kinases promote the activity of cytosolic NAD kinase (NADK), which produces NADP, a limiting NADPH precursor.
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- Mercury is a toxic substance that accumulates in fish, particularly in its organic form, methylmercury (MeHg), which poses risks to human health through contaminated fish consumption.
- Understanding how mercury accumulates in aquatic species requires analyzing several biokinetic parameters, including uptake rate, assimilation efficiency, and efflux rate, which were studied across 38 fish and 34 aquatic invertebrate species, yielding 502 total data points.
- The study found that the form of mercury and various environmental factors like water type and organism weight significantly influenced these parameters, highlighting differences between fish and invertebrates, and challenging previous assumptions about the impact of environmental conditions on mercury accumulation in aquatic ecosystems.
Background And Aims: EUS-guided gastroenterostomy (EUS-GE) has emerged as an alternative to surgical gastrojejunostomy and endoluminal stenting for malignant gastric outlet obstruction (MGOO). Studies regarding factors associated with the EUS-GE outcomes are limited.
Methods: A retrospective observational study was conducted with consecutive patients who underwent EUS-GE for MGOO from January 2016 to November 2023.
Tissues store excess nutrients as triglyceride or glycogen, but how these reserves are sensed and communicate remains poorly understood. Here we identify molecular players orchestrating this metabolic balance during fat depletion. We show fat body (FB)-specific depletion of fatty acyl-CoA synthase FASN1 in Drosophila causes near-complete fat loss and metabolic remodeling that dramatically elevates glycogen storage and carbohydrate metabolism.
View Article and Find Full Text PDFBackground: Integrated behavioral health care (IBH), a team-based approach to care, involves behavioral health providers (BHP) to be utilized in primary care settings. Unfortunately, many BHP and primary care advanced practice nursing students do not receive IBH content in their educational curriculum. This article describes an innovative interprofessional simulation project (ISP) in a virtual IBH setting with primary care nurse practitioner and master's level counseling students.
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