Publications by authors named "T D Majumdar"
The folding of the guanine repetitive region in the telomere unit into G-quadruplex (G4) by drugs has been suggested as an alternative approach for cancer therapy. Hydroxychloroquine (HCQ) and chloroquine (CQ) are two important drugs in the trial stage for cancer. Both drugs can induce the folding of telomere-guanine-rich sequences into G4 even in the absence of salt.
View Article and Find Full Text PDFBackground: Traditional and fermented foods are widely consumed by the ethnic population of Northeast India. These foods are not only very nutritious, easily available, and reasonably priced, but also boost immunity and protect from various seasonal infections and have been reported through several investigations. However, pathogens transmitted by these foods have never been reported.
View Article and Find Full Text PDFCD36 inhibition corrects lipid-FetuinA mediated insulin secretory defects by preventing intracellular lipid accumulation and inflammation in the pancreatic beta cells.
Biochim Biophys Acta Mol Basis Dis
February 2025
Article Synopsis
- CD36 is a protein that helps with fat uptake and immune response, and it's found to be more active in the pancreatic islets of obese diabetic people, which can lead to issues with insulin secretion.
- The study found that when beta cells were exposed to a combination of palmitate (a fatty acid) and fetuinA (a protein linked to inflammation), it triggered an inflammatory response that worsened lipid buildup and insulin secretion problems.
- Inhibiting CD36 or the inflammatory receptor TLR4 helped reduce this lipid accumulation and restored insulin secretion in beta cells, indicating that targeting CD36 could be a potential treatment for obesity-related beta cell dysfunction.
Introduction: From 2020, with advent of COVID-19 pandemic, Tripura has experienced SARS-CoV-2 viral evolution in accordance with other parts of India. Since January 2022, the Omicron variant of SARS-CoV-2 virus became the predominant lineage circulating in India and neighboring countries. This study characterizes the viral genome of the omicron variant circulating in the state since its inception to June, 2023.
View Article and Find Full Text PDFArticle Synopsis
- - Food safety is a serious global issue, especially in India’s North-East region, where fermented foods have led to numerous diarrheal outbreaks, but there is a lack of systematic data on foodborne pathogens.
- - The research aims to create an integrated surveillance system to monitor enteric pathogens in humans, food animals, and the environment, improving outbreak investigations in North-East India.
- - The Indian Council of Medical Research (ICMR) is leading a study to gather data through laboratory surveillance at various locations, utilizing a centralized digital database for better management and analysis of foodborne diseases.