Advancements in gene therapies targeting mutant KRAS in cancers.

Mutations in the KRAS gene are well-known tumourigenic drivers of colorectal, pancreatic and lung cancers. Mechanistically, these mutations promote uncontrolled cell proliferation and alter the tumour microenvironment during early carcinoma stages. Given their critical carcinogenic functions, significant progress has been made in developing KRAS inhibitors for cancer treatment.

Social support and cognitive reappraisal in adolescent females: The moderating role of lifetime stressor exposure.

Although social support is known to shape how individuals use emotion regulation strategies such as cognitive reappraisal, little is known about the specific dimensions of social support that facilitate such use and whether this use is moderated by lifetime stressor exposure. To investigate, we harnessed data from 47 adolescent females who participated in the Psychobiology of Stress and Adolescent Depression (PSY SAD) study to examine how six dimensions of social support related to youths' use of cognitive reappraisal. In addition, we investigated whether lifetime stressor exposure moderated the association between social support and cognitive reappraisal use in this sample.

Micro-nanoscale polystyrene co-exposure impacts the uptake and translocation of arsenic and boscalid by lettuce (Lactuca sativa).

The influence of micro-nanoplastics (MNPs) on the fate and effects of other pollutants present in the environment is largely unknown. This study evaluated if the root exposure to MNPs (polystyrene, PS; 20 or 1000 nm) had an impact on the accumulation of arsenic and boscalid (As and Bos) in lettuce (Lactuca sativa). Under hydroponic conditions, plants were co-exposed to MNPs at 10 or 50 mg/L, and to 1 mg/L of each environmental pollutant (EP).

Systematic Review on Efficacy, Effectiveness, and Safety of Pitavastatin in Dyslipidemia in Asia.

Dyslipidemia, a significant risk factor for cardiovascular disease (CVD), is marked by abnormal lipid levels, such as the elevated lowering of low-density lipoprotein cholesterol (LDL-C). Statins are the first-line treatment for LDL-C reduction. Pitavastatin (PIT) has shown potential in lowering LDL-C and improving high-density lipoprotein cholesterol (HDL-C).

Immunohistochemical Evaluation of Basal and Luminal Markers in Bladder Cancer: A Study from a Single Institution.

Background: Bladder cancer (BC) presents significant molecular diversity, which affects both prognosis and treatment results. Immunohistochemistry (IHC) facilitates the identification of molecular subtypes and their relationships with clinicopathological features.

Methods: We performed an IHC analysis on tissue samples from 107 BC patients, evaluating the expression of markers GATA3, CD44, CK5/6, and CK20.