Publications by authors named "T D Bonilla"
Background: Community-acquired UTI is the most common bacterial infection managed in general medical practice that can lead to life-threatening outcomes. While UTIs are primarily caused by colonizing the patient's gut, it is unclear whether the gut resident profiles can predict the person's risks for UTI and optimal antimicrobial treatments. Thus, we conducted an eighteen-month long community-based observational study of fecal colonization and UTI in women aged 50 years and above.
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- The study examines the impact of decreased ciprofloxacin prescriptions on the prevalence of ciprofloxacin-resistant E. coli in the gut of non-antibiotic-taking women aged 50+ from 2015 to 2021.
- Despite the reduction in prescriptions, the rates of ciprofloxacin-resistant E. coli increased from 14.2% to 19.8%, particularly in the multi-drug resistant group ST1193.
- The research suggests that managing gut microbiota is crucial for tackling urinary tract infections that are resistant to current antibiotics, as co-resistance to other antibiotics also rose significantly.
CRISPR-Cas technology has rapidly changed life science research and human medicine. The ability to add, remove, or edit human DNA sequences has transformative potential for treating congenital and acquired human diseases. The timely maturation of the cell and gene therapy ecosystem and its seamless integration with CRISPR-Cas technologies has enabled the development of therapies that could potentially cure not only monogenic diseases such as sickle cell anemia and muscular dystrophy, but also complex heterogenous diseases such as cancer and diabetes.
View Article and Find Full Text PDFFluoroquinolone use for urinary tract infections has been steadily declining. Gut microbiota is the main reservoir for uropathogenic but whether the carriage of fluoroquinolone-resistant has been changing is unknown. .
View Article and Find Full Text PDFAccuracy of 3-dimensional curvilinear measurements on digital models with intraoral scanners.
Am J Orthod Dentofacial Orthop
September 2017
Introduction: Our objectives were to evaluate and compare the digital dental models generated from 2 commercial intraoral scanners with manual measurements when performing 3-dimensional surface measurements along a curved line (curvilinear).
Methods: Dry mandibles (n = 61) with intact dentition were used. The mandibles were digitized using 2 chair-side intraoral scanners: Cadent iTero (Align Technology, San Jose, Calif) and Lythos Digital Impression system (Ormco, Orange, Calif).