Publications by authors named "T D Bartley"
Article Synopsis
- The AJCC 8th edition guidelines recommend sentinel lymph node (SLN) biopsy for primary melanomas with at least 1 mm Breslow thickness, while the NCCN considers it for certain thinner lesions with specific adverse features.
- The introduction of the Sentinella gamma camera enhances SLN identification rates during surgery, improving accuracy over traditional methods.
- At the California Pacific Medical Center, a multidisciplinary approach involving various specialists collaborates to provide personalized and effective treatment for melanoma patients, and this model can be applied to other cancer types as well.*
Article Synopsis
- Tandem repeat (TR) variation is linked to gene expression and rare genetic diseases, and there's a demand for better tools to analyze these variations across genomes.
- The Tandem Repeat Genotyping Tool (TRGT) is introduced as a computational method designed to determine consensus sequences and methylation levels of TRs using PacBio HiFi sequencing data.
- TRGT demonstrated high accuracy with a 98.38% Mendelian concordance and successfully identified known repeat expansions and their methylation status in samples, while also providing access to a database of TR sequences and methylation levels from 100 genomes.
Objective: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset progressive genetic neurodegenerative disorder that occurs in FMR1 premutation carriers. The temporal, spatial, and cell-type specific patterns of neurodegeneration in the FXTAS brain remain incompletely characterized. Intranuclear inclusion bodies are the neuropathological hallmark of FXTAS, which are largest and occur most frequently in astrocytes, glial cells that maintain brain homeostasis.
View Article and Find Full Text PDFQuantum photonic processing via electro-optic components typically requires electronic links across different operation environments, especially when interfacing cryogenic components such as superconducting single photon detectors with room-temperature control and readout electronics. However, readout and driving electronics can introduce detrimental parasitic effects. Here we show an all-optical control and readout of a superconducting nanowire single photon detector (SNSPD), completely electrically decoupled from room temperature electronics.
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