Publications by authors named "T D'Hooghe"
Background: The ovarian response to gonadotropin stimulation varies widely among women, and could impact the probability of live birth as well as treatment risks. Many studies have evaluated the impact of different gonadotropin starting doses, mainly based on predictive variables like ovarian reserve tests (ORT) including anti-Müllerian hormone (AMH), antral follicle count (AFC), and basal follicle-stimulating hormone (bFSH). A Cochrane systematic review revealed that individualizing the gonadotropin starting dose does not affect efficacy in terms of ongoing pregnancy/live birth rates, but may reduce treatment risks such as the development of ovarian hyperstimulation syndrome (OHSS).
View Article and Find Full Text PDFObjective: Various gonadotropins are used for ovarian stimulation (OS). This study investigated the cost-effectiveness of different gonadotropins based on real-world data from the French National Health Database (SNDS) over a 7-year follow-up of assisted reproductive technology (ART) treatments.
Design: Cost-effectiveness analysis of different gonadotropins based on real-world data from the SNDS was conducted.
Article Synopsis
- A panel of international experts evaluated and discussed the POSEIDON criteria, aiming to improve management strategies for women with low prognosis in assisted reproductive technology (ART).
- Through a Delphi consensus process involving multiple rounds of voting, 53 experts reviewed 17 statements and reached consensus on their relevance for patient care and outcomes in ART.
- Key recommendations include using specific treatments and tools to enhance success rates, while emphasizing the need for more large-scale studies to validate existing findings.
Article Synopsis
- The objective of the study is to evaluate how well ovarian stimulation (OS) promotes follicular development and retrieves quality oocytes by examining antral follicle count (AFC) and its relationship to oocyte outcomes.
- The study emphasizes the need to enhance the key performance indicators (KPIs) used to assess OS effectiveness, introducing new metrics like "early FORT" and "modified FORT" for better evaluation of follicular growth and oocyte retrieval rates.
- The researchers advocate for incorporating these refined KPIs into clinical practices to improve the assessment of OS and its impact on ovarian follicular development, ultimately aiming for individualized treatments in assisted reproductive technology.
Article Synopsis
- The clinical management of women with diminished ovarian reserve (DOR) poses challenges, particularly due to inconsistent definitions of DOR across studies.
- This research aims to evaluate various adjuvant treatments for women with DOR based on the POSEIDON criteria, analyzing data from numerous studies published until June 2024.
- The analysis includes 38 randomized controlled trials, identifying testosterone supplementation as a treatment associated with higher live birth rates in women with DOR compared to those who did not receive supplementation.