Publications by authors named "T Cvjetkovic"
Comparative Effects of Target-Controlled Infusion of Propofol Versus Spinal and Thiopental-Sevoflurane Anesthesia on Lipid Peroxidation in Elective Cesarean Section: A Prospective, Open-Label Study.
Cureus
June 2024
Article Synopsis
- The study investigates how different anesthesia methods during cesarean sections affect oxidative stress levels in mothers and fetuses, specifically focusing on propofol versus spinal and thiopental-sevoflurane anesthesia.
- Ninety women undergoing elective cesarean sections were divided into three groups, with blood samples collected at various times to measure oxidative stress using the TBARS assay.
- Results showed that propofol anesthesia significantly lowered oxidative stress markers (TBARS levels) compared to spinal and thiopental-sevoflurane anesthesia, with lower values noted after induction and post-surgery.
Article Synopsis
- Bacterial lipopolysaccharide (LPS) triggers inflammation through cytokine release and can lead to serious tissue damage and organ failure, making it crucial to find effective treatments.
- In a study on rats, researchers tested the effects of two bile acids, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA), and found that both significantly reduced inflammation, improved antioxidant levels, and helped protect against liver injury induced by LPS.
- Although both bile acids were beneficial, UDCA showed a more pronounced impact on reducing harmful serum markers, highlighting different protective roles of these compounds against LPS-induced damage.
Background: Isoprenaline (ISO), a synthetic catecholamine and a β-adrenoceptor agonist, is widely used to develop an experimental model of myocardial injury (MI) in rats. The leading hypothesis for ISO-induced MI in rats is that it results from catecholamine overstimulation, oxidative stress, inflammatory responses, and development of cardiomyopathy during ISO administration. Folic acid (FA) reduces oxidative stress, improves endothelial function and prevents apoptosis, thereby contributing to cardiovascular protection.
View Article and Find Full Text PDFTakotsubo syndrome (TTS) is an acute heart failure syndrome characterised by catecholamine-induced oxidative tissue damage. , a fruit-bearing tree, is known to have high polyphenolic content and has been proven to be a potent antioxidant. This study aimed to investigate the effects of pomegranate peel extract (PoPEx) pre-treatment on isoprenaline-induced takotsubo-like myocardial injury in rats.
View Article and Find Full Text PDFType 2 diabetes mellitus (T2DM) increases the risk of cardiovascular disease, especially myocardial injury. Due to their hypoglycemic effects, glucagon-like peptide-1 receptor agonists (GLP-1RAs) are efficiently used for T2DM management. GLP-1RAs also have anti-inflammatory and antioxidative effects and can improve cardiac function.
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