Publications by authors named "T Cross"
CrgA is a key transmembrane (TM) protein in the cell division process of (), the pathogen responsible for tuberculosis. While many of the divisome proteins have been identified, their structures and interactions remain largely unknown. Previous studies of CrgA using oriented-sample solid-state NMR have defined the tilt and rotation of the TM helices, but the cytoplasmic and periplasmic domains and even the oligomeric state were uncharacterized.
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- Oxygen is crucial for biomolecular structures, but its low natural abundance complicates the use of O NMR in research.
- A new method has been developed for quick and cost-effective O-labeling of specific amino acids in recombinant proteins, using a fast synthesis process with a bacterial expression system.
- This technique has successfully produced O-labeled proteins from various organisms, enhancing O NMR's accessibility and providing valuable insights into protein structures and interactions at the molecular level.
Introduction: COPD is characterised by airflow obstruction, expiratory airway collapse and closure causing expiratory flow limitation (EFL) and hyperinflation. Supine posture may worsen ventilatory function in COPD, which may cause hyperinflation to persist and contribute to symptoms of orthopnoea and sleep disturbance. Our aim was to determine the impact of supine posture on hyperinflation, dynamic elastance and EFL in COPD and healthy subjects.
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- A maximal apnoea poses significant challenges to the body, impacting arterial blood gases and requiring complex responses from multiple physiological systems like blood pressure and cerebral blood flow.
- Previous research has largely concentrated on cardiovascular responses during maximal apnoea, with limited exploration into respiratory muscle responses and respiratory mechanics.
- This review suggests that respiratory muscles may fatigue after maximal apnoea and proposes that elite divers may possess greater fatigue resistance, which could contribute to their success; it also highlights the need for further studies on the long-term health effects of apnoea diving.
Synbiotics may be useful to mitigate intestinal diseases such as ulcerative colitis. Here we show that combining 13'-carboxychromanol (δT3-13'), a metabolite of vitamin E δ-tocotrienol (δT3) via omega-oxidation, and Lactococcus lactis subsp. cremori (L.
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