Publications by authors named "T Craig Timm"
"True" cobras (genus ) are among the venomous snakes most frequently involved in snakebite accidents in Africa and Asia. The Cape cobra () is one of the African cobras of highest medical importance, but much remains to be learned about its venom. Here, we used a shotgun proteomics approach to better understand the qualitative composition of venom and tested its cytotoxicity and protease activity as well as its effect on intracellular Ca release and NO synthesis.
View Article and Find Full Text PDFSnakebite primarily impacts rural communities of Africa, Asia, and Latin America. The sharp-nosed viper (Deinagkistrodon acutus) is among the snakes of highest medical importance in Asia. Despite various studies on its venom using modern venomics techniques, a comprehensive understanding of composition and function of this species' venom remains lacking.
View Article and Find Full Text PDFThe (patho)physiological function of the sphingolipids ceramide-1-phosphate (C1P), sphingosine-1-phosphate (S1P), and sphingosylphosphorylcholine (SPC) in articular joints during osteoarthritis (OA) is largely unknown. Therefore, we investigated the influence of these lipids on protein expression by fibroblast-like synoviocytes (FLSs) from OA knees. Cultured human FLSs ( = 7) were treated with 1 of 3 lipid species-C1P, S1P, or SPC-IL-1β, or with vehicle.
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- This paper studies the effects of new bioproducts made from peach palm shells on beef cattle diets, focusing on ruminal fermentation and greenhouse gas emissions.
- In vitro tests showed that these bioproducts have high levels of β-glucans and protein, and their digestibility is comparable to traditional diets.
- The SMS diet resulted in lower methane and carbon dioxide production compared to other diets, suggesting that these new bioproducts are a sustainable option for improving nutritional value and reducing environmental impact in beef cattle farming.
Article Synopsis
- Venoms are a great example of how similar traits can evolve independently in different animal groups, but there's limited research on toxin genes in most species, especially in hymenopteran insects like bees.
- A study examined the origins of 11 toxin genes across 32 hymenopteran genomes, finding that most venom genes developed from single gene co-option and further diversified through gene duplication.
- The research revealed that most venom genes are common to all hymenopterans, with only a few like melittin and anthophilin1 being exclusive to bees, suggesting these venom proteins existed before the significant diversification of this insect group.