Lanreotide Autogel in the Treatment of Idiopathic Refractory Diarrhea: Results of an Exploratory, Controlled, Before and After, Open-label, Multicenter, Prospective Clinical Trial.

Purpose: Chronic idiopathic diarrhea is the passage of loose stools >3 times daily, or a stool weight >200 g/d, persisting for >4 weeks without clear clinical cause. Patients refractory to standard anti-diarrhetics have limited treatment options. Somatostatin analogues have the ability to reduce gastrointestinal secretions and motility.

[Klebsiella pneumoniae septicaemia and meningitis in a diabetic patient with an hepatic abscess].

Klebsiella pneumoniae infections show particular features depending on the geographical localization as well as comorbidity factors. We are presenting the case of a european patient with diabetes mellitus who presented a septicaemia, a meningitis as well as an hepatic abscess due to a K. pneumoniae and whose evolution was excellent under antibiotics.

[How to detect the complications of the cirrhosis?].

The occurrence of complications marks a turn in the natural history of cirrhosis. The early management, the etiologic treatment of the subjacent disease, the methodological detection of hepatocarcinoma, the prophylaxis of digestive bleeding linked to portal hypertension, the control of ascite and prevention of hepato-renal syndrome allow to improve the prognosis of these patients. Moreover, bacterial infection represents one of the principal factor facilitating the occurrence of another complication.

Effects of clonidine on diuretic response in ascitic patients with cirrhosis and activation of sympathetic nervous system.

The effects of the addition of clonidine to diuretics on the mobilization of ascites in the short term (diuretic response and requirement of diuretics) and the long term (readmissions for tense ascites and requirement of diuretics) were examined in patients with cirrhosis and with increased sympathetic nervous system (SNS) activity. We also studied neurohormonal, hemodynamic effects and side effects of clonidine and diuretics. Patients were randomized to receive placebo (group 1, n = 32) or clonidine (0.

Comparative pilot study of repeated large volume paracentesis vs the combination on clonidine-spironolactone in the treatment of cirrhosis-associated refractory ascites.

Objectives: To study the usefulness of the combination of clonidine--spironolactone in refractory ascites.

Methods: Twenty cirrhotic patients with refractory ascites were randomly assigned to receive repeated large volume paracentesis plus intravenous albumin (group 1), or a combination of clonidine (0.075 mg twice daily) and spironolactone (200 to 400 mg daily) (group 2).