Mapping the effectiveness and risks of GLP-1 receptor agonists.

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) are increasingly being used to treat diabetes and obesity. However, their effectiveness and risks have not yet been systematically evaluated in a comprehensive set of possible health outcomes. Here, we used the US Department of Veterans Affairs databases to build a cohort of people with diabetes who initiated GLP-1RA (n = 215,970) and compared them to those who initiated sulfonylureas (n = 159,465), dipeptidyl peptidase 4 (DPP4) inhibitors (n = 117,989) or sodium-glucose cotransporter-2 (SGLT2) inhibitors (n = 258,614), a control group composed of an equal proportion of individuals initiating sulfonylureas, DPP4 inhibitors and SGLT2 inhibitors (n = 536,068), and a control group of 1,203,097 individuals who continued use of non-GLP-1RA antihyperglycemics (usual care).

Novel application of an imageless robotic system in simultaneous unicompartmental knee arthroplasty and anterior cruciate ligament reconstruction.

This technical note explores the novel use of an imageless robotic surgical system for simultaneous unicompartmental knee arthroplasty (UKA) and anterior cruciate ligament reconstruction (ACLR). Knee osteoarthritis (OA) and anterior cruciate ligament (ACL) insufficiency are common conditions that traditionally require separate management. The integration of robotic assistance offers enhanced precision in surgical procedures, addressing both medial compartment OA and ACL insufficiency in a single operation.

Treatment effects of modified miniscrew-assisted rapid palatal expander and rapid palatal expander for molar distalization.

Objectives: To evaluate the treatment effects of the modified miniscrew-assisted rapid palatal expander (MARPE) and rapid palatal expander (RPE) with distalizers in patients with Class II malocclusion and maxillary crowding.

Materials And Methods: The sample comprised 28 skeletal Class I adolescents with dental Class II malocclusion and maxillary crowding of >4 mm who received nonextraction treatment. Fourteen patients were treated with a modified MARPE with distalizer (MMD), while another 14 patients were treated with a modified RPE with distalizer (MRD).

Air and Thermally Stable Cyclic (Alkyl)(amino)carbene Ruthenium Complexes for Efficient Ring Expansion Metathesis Polymerization.

Ring expansion metathesis polymerization (REMP) has emerged as a potent strategy for obtaining cyclic polymers over the past two decades. The scope of monomers, however, remains limited due to the poor functional group tolerance and stability of the catalyst, necessitating a rational catalyst design to address this constraint. Here, we present ruthenium complexes featuring tethered cyclic (alkyl)(amino)carbene ligands for REMP, aiming to deepen our understanding of the structure-property relationship in newly designed catalysts.

Etching Chemistry Process Optimization of Ethylene Diluted with Helium (CH/He) in Interconnect Integration.

This study explores the effects of different passivation gases on the properties of polymers formed on aluminum (Al) sidewalls during the etching process in Al-based interconnect structures. The research compares the use of nitrogen (N) and ethylene diluted with helium (CH/He) as passivation gases, focusing on the resulting polymer's composition, thickness, and strength, as well as the levels of residual chlorine post-etch. The findings reveal that using CH leads to the formation of a thinner, weaker polymer with lower chlorine residue compared to the thicker, stronger polymer formed with N.