Publications by authors named "T Chappell"

is a globally significant genus of plant pathogens known for causing anthracnose across a diverse array of hosts. Notably, is a pathogen affecting maize. Annually, the global economic impact of this pathogen reaches billions of US dollars.

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The profound stability of bacterial spores makes them a promising platform for biotechnological applications like biocatalysis, bioremediation, drug delivery, etc. However, though the spore is composed of >40 proteins, only ∼12 have been explored as fusion carriers for protein display. Here, we assessed the suitability of 33 spore proteins (SPs) as enzyme display carriers by direct allele tagging at native genomic loci.

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Article Synopsis
  • The study examined the use of machine learning (ML) to predict bloodstream infections (BSIs) in children with acute myeloid leukemia (AML) who underwent intensive chemotherapy at Children's Minnesota from 2005 to 2019.
  • Over half (54.7%) of the 95 AML patients experienced BSIs, with higher doses of the chemotherapy drug cytarabine increasing the risk, while levofloxacin-vancomycin prophylaxis significantly reduced it.
  • The best ML model utilized was regularized logistic regression, which showed a predictive ability better than traditional methods based on neutropenia and fever, highlighting the potential of ML in clinical settings to manage sensitivity and specificity for BSI diagnosis.
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Plant diseases significantly impact food security and food safety. It was estimated that food production needs to increase by 50% to feed the projected 9.3 billion people by 2050.

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Prior to the recent implementation of the Mpp51Aa2 pesticidal protein (ThryvOn), transgenic cotton cultivars have historically offered no control of the cotton fleahopper ( (Reuter)). To evaluate the feeding behavior of cotton fleahoppers on ThryvOn cotton, electropenetrography (EPG) using a Giga-8 DC instrument was used to monitor the probing activity of fourth- and fifth-instar cotton fleahopper nymphs on both ThryvOn and non-ThryvOn cotton squares. Nymphs were individually placed on an excised cotton square for 8 h of EPG recording, after which resulting waveforms were classified as non-probing, cell rupturing, or ingestion.

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