Publications by authors named "T Chapelle"
Article Synopsis
- The study evaluated the prognostic significance of total tumor volume (TTV) in predicting early recurrence and overall survival in patients with colorectal liver metastases (CRLM) who received systemic therapy followed by local treatment.
- Results showed that both baseline TTV and changes in TTV after treatment were significantly associated with early recurrence and overall survival, while conventional measures like RECIST1.1 did not show predictive value.
- Findings were validated in an external patient cohort, confirming that TTV provides important prognostic information beyond traditional clinical factors for patients with initially unresectable CRLM.
Article Synopsis
- Researchers developed deep learning models to automate the segmentation of tumors and assess total tumor volume (TTV) in patients with colorectal liver metastases (CRLM).
- The study used CT scans from 259 patients, dividing them into training, validation, and testing sets, resulting in highly accurate segmentation models with a global Dice similarity coefficient of 0.86 for CRLM.
- The findings suggest that these models can significantly reduce the workload for radiologists by allowing for quick and reliable TTV assessments in patients with CRLM.
Background: Liver transplantation (LT) is a strenuous event for the cardiovascular system. Cardiovascular events (CVE), including heart failure (HF), arrhythmias and myocardial ischemia, are important causes of peri- and post-liver transplantation morbidity and mortality.
Case Presentation: We describe the case of a 45-year-old male patient who developed heart failure with severely reduced ejection fraction (HFrEF) after receiving liver transplantation (LT) for end-stage post-alcoholic liver cirrhosis.
Article Synopsis
- Patients undergoing pancreatic surgery are at risk of pancreatic exocrine insufficiency (PEI), which often requires pancreatic enzyme replacement therapy (PERT).
- In a study with 254 patients, those who had pancreaticoduodenectomy showed a significant decline in pancreatic function post-surgery, with 68% requiring PERT after the operation.
- Systematic screening for PEI after pancreaticoduodenectomy is essential, especially since patients with a main pancreatic duct diameter over 3 mm are at higher risk for developing this condition.
Intersurgeon Variability in Local Treatment Planning for Patients with Initially Unresectable Colorectal Cancer Liver Metastases: Analysis of the Liver Expert Panel of the Dutch Colorectal Cancer Group.
Ann Surg Oncol
September 2023
Background: Consensus on resectability criteria for colorectal cancer liver metastases (CRLM) is lacking, resulting in differences in therapeutic strategies. This study evaluated variability of resectability assessments and local treatment plans for patients with initially unresectable CRLM by the liver expert panel from the randomised phase III CAIRO5 study.
Methods: The liver panel, comprising surgeons and radiologists, evaluated resectability by predefined criteria at baseline and 2-monthly thereafter.