Publications by authors named "T Catania"
The monoterpene camphor is produced in glandular secretory trichomes of the medicinal plant , which also produces the antimalarial drug artemisinin. We have found that, depending on growth conditions, camphor can accumulate at levels ranging from 1- 10% leaf dry weight (LDW) in the Artemis F1 hybrid, which has been developed for commercial production of artemisinin at up to 1% LDW. We discovered that a camphor null (camphor-0) phenotype segregates in the progeny of self-pollinated Artemis material.
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- The STORR gene fusion is crucial for the creation of certain alkaloids in opium poppy by enabling a key protein to convert (S)-reticuline to (R)-reticuline, necessary for turn into promorphinans and morphinans.
- Research shows that among 12 Papaver species examined, those with the STORR fusion typically produce these alkaloids, except P. californicum, which, despite having the gene, does not synthesize them.
- The gene fusion is estimated to have occurred 16.8-24.1 million years ago before P. californicum diverged from other Papaver species, suggesting that STORR may also play a role in
is established as an efficient crop for the production of the anti-malarial compound artemisinin, a sesquiterpene lactone synthesized and stored in Glandular Secretory Trichomes (GSTs) located on the leaves and inflorescences. synthase (AMS) catalyzes the conversion of farnesyl pyrophosphate (FPP) to amorpha-4,11-diene and diphosphate, which is the first committed step in the synthesis of artemisinin. FPP is the precursor for sesquiterpene and sterol biosynthesis in the plant.
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