Publications by authors named "T Casoli"
Alzheimer's disease (AD) accounts for the majority of dementia cases, with aging being the primary risk factor for developing this neurodegenerative condition. Aging and AD share several characteristics, including the formation of amyloid plaques and neurofibrillary tangles, synaptic loss, and neuroinflammation. This overlap suggests that mechanisms driving the aging process might also promote AD; however, the underlying processes are not yet fully understood.
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- Major depressive disorder (MDD) is a serious mental health issue especially prevalent in older adults, often going untreated and leading to high rates of disability and mortality.
- New therapeutic approaches are needed for geriatric MDD patients, focusing on microRNAs that target Brain-Derived Neurotrophic Factor (BDNF), which is reduced in those with MDD.
- The review highlights the importance of using multiple microRNAs together and explores delivery methods, suggesting liposomes as the best option for treatment administration despite the challenges in developing the perfect delivery vehicle.
COVID-19 remains a serious concern for elderly individuals with underlying comorbidities. SARS-CoV-2 can target and damage mitochondria, potentially leading to mutations in mitochondrial DNA (mtDNA). This study aimed to evaluate single nucleotide substitutions in mtDNA and analyze their correlation with inflammatory biomarkers in elderly COVID-19 patients.
View Article and Find Full Text PDFBackground: ALS is a heterogeneous disease in which different factors such as mitochondrial phenotypes act in combination with a genetic predisposition. This study addresses the question of whether homoplasmic (total mitochondrial genome of a sample is affected) and/or heteroplasmic mutations (wildtype and mutant mitochondrial DNA molecules coexist) might play a role in familial ALS. Blood was drawn from familial ALS patients with a possible maternal pattern of inheritance according to their pedigrees, which was compared to blood of ALS patients without maternal association as well as age-matched controls.
View Article and Find Full Text PDFBackground: Numerous mouse models of Alzheimer's disease (AD) are available, but all suffer from certain limitations, thus prompting further attempts. To date, no one model exists with amyloidopathy in a BALB/c strain.
Objective: To generate and characterize the C.