Publications by authors named "T Carrillo"
Rationale: Biologics are becoming increasingly important in the management of severe asthma. However, little is known about the systemic immunometabolic consequences of Th2 response blockage.
Objectives: To provide a better immunometabolic understanding of the effects of mepolizumab and omalizumab treatments by identifying potential biomarkers for monitoring.
The mechanisms underlying severe allergic asthma are complex and unknown, meaning it is a challenge to provide the most appropriate treatment. This study aimed to identify novel biomarkers for stratifying allergic asthmatic patients according to severity, and to uncover the biological mechanisms that lead to the development of the severe uncontrolled phenotype. By using miRNA PCR panels, we analyzed the expression of 752 miRNAs in serum samples from control subjects ( = 15) and mild ( = 11) and severe uncontrolled ( = 10) allergic asthmatic patients.
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- High-dose methotrexate (HDMTX) can cause acute kidney injury (AKI), making early detection crucial to prevent further damage.
- A study analyzed MTX elimination patterns as potential biomarkers for AKI in patients undergoing HDMTX treatment, utilizing ROC curves to identify significant markers.
- Results showed that early MTX elimination times are linked to AKI risk, suggesting that monitoring these patterns can help tailor patient care, including hydration and treatment adjustments.
encode a conserved accessory gene within the +1 open reading frame (ORF) of nucleocapsid called the internal N gene. This gene is referred to as "I" for mouse hepatitis virus (MHV), ORF9b for severe acute respiratory CoV (SARS-CoV) and SARS-CoV-2, and ORF8b for Middle East respiratory syndrome CoV (MERS-CoV). Previous studies have shown ORF8b and ORF9b have immunoevasive properties, while the only known information for MHV I is its localization within the virion of the hepatotropic/neurotropic A59 strain of MHV.
View Article and Find Full Text PDFImpact of Climate Change-Related Environmental Factors on Allergen Production and the Epidemiology and Severity of Allergic Diseases.
J Investig Allergol Clin Immunol
December 2024
Background: Allergic disease affects up to 40% of the adult population worldwide. This percentage is increasing as a result of environmental changes related to global warming.
Methods: We undertook a systematic review of the literature to identify and evaluate current evidence on the impact of climate change-related environmental factors on allergen production and the epidemiology and severity of allergic diseases.